R&D: Achieve Handle Level Random Access in Encrypted DNA Archival Storage System via Frequency Dictionary Mapping Coding

BioRxiv has published an article written by Ben Cao, School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China, and Centre for Frontier AI Research, Agency for Science, Technology and Research (A*STAR), Singapore 138632, Singapore, Xue Li, School of Computer Science and Technology, China University of Petroleum, Qingdao 266580, China, and The Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, China, Bin Wang, The Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, China, Tiantian He, Centre for Frontier AI Research, Agency for Science, Technology and Research (A*STAR), Singapore 138632, Singapore, and School of Computer Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore, Yanfen Zheng, Xiaokang Zhang, and Qiang Zhang, School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China.

Abstract: “DNA as a storage medium has the characteristics of high storage density and durability, but the existing DNA storage system has a high latency, and lacks the consideration of data security. In order to improve the availability of DNA storage, this paper proposes that Frequency Dictionary Mapping Coding (FDMC) implements handle-level random access in DNA Archival storage, and a hybrid e-molecular encryption strategy and multi-level error correction algorithm are provided to ensure data security and integrity. The results of the simulation and wet experiments demonstrate that FDMC can achieve handle-level random access in lossless encrypted DNA storage systems, which balances security and convenience. In terms of read and write consistency, FDMC has significant advantages in storage density and robustness of data recovery. Even in the extreme case of DNA sequence loss of 10%, it can still recover 91.74% of the original data while ensuring storage density above 1.80 bits/nt. In summary, FDMC improves the application range of DNA as a storage medium and bridges the gap between DNA storage and traditional storage modes in the storage and reading of large-scale archives.“