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R&D: Zettabyte Era is in our DNA

Perspective surveys critical computational challenges associated with in vitro DNA-based data storage.

Nature Computational Science has published an article written by Daniella Bar-Lev, Omer Sabary, and Eitan Yaakobi, The Henry and Marilyn Taub Faculty of Computer Science, Technion, Israel Institute of Technology, Haifa, Israel.

Abstract: This Perspective surveys the critical computational challenges associated with in vitro DNA-based data storage. As digital data expand exponentially, traditional storage media are becoming less viable, making DNA a promising solution due to its density and durability. However, numerous obstacles remain, including error correction, data retrieval from large volumes of noisy reads, and scalability. The Perspective also highlights challenges for DNA-based data centers, such as fault tolerance, random access, and data removal, which must be addressed to make DNA-based storage practical.

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